Bis(acetato)amminedichloro(cyclohexylamine)platinum(IV), an Orally Active Anticancer Drug
- 15 May 1995
- journal article
- other
- Published by International Union of Crystallography (IUCr) in Acta Crystallographica Section C Crystal Structure Communications
- Vol. 51 (5) , 822-824
- https://doi.org/10.1107/s0108270194013600
Abstract
The structure of the anticancer drug bis(acetato)-amminedichloro(cyclohexylamine)platinum(IV), [PtCl2-(C2H3O2)2(C6H13N)(NH3)], is reported. The acetato groups are axial to the square plane composed of the chlorine and amine substituents. The cyclohexane ring may sterically hinder one of the acetato groups for metabolic attack. The amine groups are hydrogen bonded to the carbonyl O atoms of the acetato groups.Keywords
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