HUMAN-SERUM ZN-ALPHA2-GLYCOPROTEIN IN RENAL-DISEASE

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  • 1 January 1976
    • journal article
    • research article
    • Vol. 25  (7) , 246-248
Abstract
The serum concentrations of Zn-.alpha.2-glycoprotein (ZnaGP) were increased in renal patients with both normal and restricted function. The latter showed significant correlation with serum creatinine and urea levels and a decrease after hemodialysis. Renal clearance of ZnaGP studied in 4 subjects was from 0.1 to 0.8% of that of inulin and its excretion fraction was inversely proportional to the level of inulin clearance. The significance of the association of hyper-ZnaGP-emia with renal pathology is unknown; it is supposed to be due rather to some defect in metabolic function of the kidney (utilization or degradation) than to restricted excretion. Its decrease after hemodialysis with dialysis membrane not permeabile to ZnaGP, is caused by other factors than by the removal of the protein from the body.

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