EFFECT OF PARENTERAL ADMINISTRATION OF A RABBIT ANTI-(MOUSE)-IGD SERUM ON IMMUNE-RESPONSE OF MICE TO SHEEP ERYTHROCYTES

  • 1 January 1978
    • journal article
    • research article
    • Vol. 35  (6) , 1027-1036
Abstract
Experiments were conducted to determine if the administration of an anti-Ig[immunoglobulin]D serum to mice interferes with their immune response to sheep red blood cells. A hypothesis that a biological role for IgD might be as a critical cellular receptor for antigen was tested. Injection of anti-IgD 2 days before antigen resulted in suppression of primary responses and priming (the antigen dependent generation of memory cells) but had no suppressive effect on a secondary response. IgD is probably present on antigen-sensitive precursor cells but not on memory cells.