Effects of hemodilution on O2 transport in high-altitude polycythemia
- 1 November 1985
- journal article
- research article
- Published by American Physiological Society in Journal of Applied Physiology
- Vol. 59 (5) , 1495-1502
- https://doi.org/10.1152/jappl.1985.59.5.1495
Abstract
A native of the Peruvian Andes (4,250 m) was studied before and after isovolemic hemodilution of the hematocrit from 62 to 42%. O2 transport was studied with newly developed catheters in the radial and pulmonary arteries. These catheters allowed continuous measurement of arterio-venous O2 content and intermittent cardiac output by thermodilution. During exercise tests, breath-by-breath gas exchange measurements also allowed cardiac output to be calculated by the O2-Fick tchnique. A complex series of interrelated physiological changes occurred in response to hemodilution. These included increased ventilation, increased arterial and mixed venous PO2, increased cardiac output (both heart rate and stroke volume), and improved ventilation-flow match. The general improvement in symptoms that followed hemodilution correlated well with increased anaerobic threshold and mixed venous PO2 during exercise.This publication has 4 references indexed in Scilit:
- Simulation of continuous blood O2 equilibrium curve over physiological pH, DPG, and Pco2 rangeJournal of Applied Physiology, 1983
- Breath-by-breath measurement of true alveolar gas exchangeJournal of Applied Physiology, 1981
- Cardiac Output Determination by Thermodilution Technique: The Method of Choice in Low Flow StatesExperimental Biology and Medicine, 1981
- INFLUENCE OF ANOXEMIA ON THE HEMOPOIETIC ACTIVITYArchives of internal medicine (1960), 1945