Estimation of Plasma Half-Lives of Vasopressin Analogs from Vasopressor Responses by Curve-Fitting

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Abstract
Vasopressor [VP] responses by rats to graded doses of AVP [arginine-VP] daVP [1-deamino-AVP] and AVT [arginine-vasotocin] were analyzed in an attempt to find a method for estimating plasma half-life from responses. The resulting curve-fit method indicated half-lives of 2.6 .+-. 0.3, 4.0 .+-. 0.3 and 9.2 .+-. 1.4 min for AVP, AVT and dAVP, respectively, after single i.v. injections. The half-lives of 2 peptides can be compared in 1 rat with the curve-fit method. This method can also provide useful information concerning the relative contributions of the plasma half-life, the log dose-response relationship, and other factors, to the duration of the response.