THEIN VITRORESIN SPONGE UPTAKE OF TRTIODOTHYRONINE-I131FROM SERUM IN THYROID DISEASE AND IN PREGNANCY*

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Abstract
A procedure has been devised which measures the uptake of I131-labeled triiodothyronine (T3-I131) from serum in vitro by means of a resin sponge. The sponge, consisting of a mixture of polyurethane foam and a finely divided anion exchange resin (Amberlite IRA-400), was equilibrated with serum containing T3-I131. Significant differences in the sponge uptake of T3-I131 from serum were demonstrated in hyperthyroidism, myxedema, and uncomplicated pregnancy when compared with the sponge uptake from the serum of normal subjects; values were elevated in hyperthyroidism and reduced in pregnancy and myxedema. Augmented sponge binding of T3-I131 was also observed following the administration of thyrotropin to subjects other than those with primary myxedema. The results indicate that the resin sponge procedure may be a useful means for distinguishing between certain thyroidal abnormalities and for recognizing pregnancy and pregnancy complicated by hyperthyroidism.