Immunohistological Changes in Dilated Cardiomyopathy Induced by Immunoadsorption Therapy and Subsequent Immunoglobulin Substitution
- 5 June 2001
- journal article
- clinical trial
- Published by Wolters Kluwer Health in Circulation
- Vol. 103 (22) , 2681-2686
- https://doi.org/10.1161/01.cir.103.22.2681
Abstract
Background—Immunoadsorption (IA) and subsequent immunoglobulin (Ig) G substitution represent an additional therapeutic approach in dilated cardiomyopathy (DCM). It remains to be elucidated whether this treatment modulates myocardial inflammation, which is possibly a causal factor of ventricular dysfunction.Methods and Results—From 25 DCM patients (EF PP2(PPP2(PPPConclusions—IA and subsequent IgG substitution mitigate myocardial inflammation in DCM.Keywords
This publication has 16 references indexed in Scilit:
- Hemodynamic effects of immunoadsorption and subsequent immunoglobulin substitution in dilated cardiomyopathyJournal of the American College of Cardiology, 2000
- Proinflammatory cytokine levels in patients with depressed left ventricular ejection fraction: A report from the studies of left ventricular dysfunction (SOLVD)Journal of the American College of Cardiology, 1996
- Myocardial enterovirus infection with left ventricular dysfunction: A benign disease compared with idiopathic dilated cardiomyopathyJournal of the American College of Cardiology, 1995
- Antibody-mediated autoimmune myocarditis depends on genetically determined target organ sensitivity.The Journal of Experimental Medicine, 1995
- Treatment of myasthenia gravis by immunoadsorption of plasmaNeurology, 1995
- Anti-β1-adrenoceptor autoantibodies with chronotropic activity from the serum of patients with dilated cardiomyopathy: Mapping of epitopes in the first and second extracellular loopsJournal of Molecular and Cellular Cardiology, 1995
- Cellular basis for the negative inotropic effects of tumor necrosis factor-alpha in the adult mammalian heart.Journal of Clinical Investigation, 1993
- Localization of a functional autoimmune epitope on the muscarinic acetylcholine receptor-2 in patients with idiopathic dilated cardiomyopathy.Journal of Clinical Investigation, 1993
- Elevated circulating levels of beta 2-microglobulin in patients with idiopathic dilated cardiomyopathyThe American Journal of Cardiology, 1993
- Manipulating the Immune System with Immune GlobulinNew England Journal of Medicine, 1992