Preparation and purification of L-(.+-.)-5-formyl-5,6,7,8-tetrahydrofolic acid
- 1 June 1979
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 22 (6) , 731-734
- https://doi.org/10.1021/jm00192a021
Abstract
Reinvestigation of the conversion of folic acid to leucovorin [L-(.+-.)-5-CHO-THF] (L-(.+-.)-5-formyl-5,6,7,8-tetrahydrofolic acid) led to improved methods for the synthesis of the drug [a rescue factor in methotrexate cancer chemotherapy] which is suitable for clinical use. Methods were developed for the chromatographic and nonchromatographic purification of less pure samples of L-(.+-.)-5-CHO-THF.This publication has 2 references indexed in Scilit:
- Liquid chromatography assay of the calcium salt of citrovorum factorJournal of Chromatography A, 1977
- Continuous infusion of methotrexate in children with acute leukemiaCancer, 1967