Quantitative relations between chemical structure and hepatotoxicity of thiobenzamides
- 1 January 1988
- journal article
- Published by Institute of Organic Chemistry & Biochemistry in Collection of Czechoslovak Chemical Communications
- Vol. 53 (11) , 2957-2961
- https://doi.org/10.1135/cccc19882957
Abstract
1H NMR chemical shifts of thioamide protons have been determined for a group of thiobenzamides, and the values obtained have been correlated with the Hammett constants. From the relations found the σm and σp values of thioamide group and some other σ constants describing the total effect of two substituents in the phenyl group have been calculated. The relation between the hepatotoxicity for rats (expressed as log ALT) and the Hammett constants is described by equation of parabola.Keywords
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