Suppressor T cells and soluble suppressor factors in allergy: effect of immunotherapy

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Abstract
Suppressor-cell activity of Concanavalin-A-stimulated lymphocytes was studied in allergic patients by inhibition of 1-way mixed lymphocytes culture reactions before and after allergy immunotherapy. This activity was compared with 12 healthy controls. In preliminary experiments, 6 of 8 allergic patients had no detectable T suppressor activity. In the 2nd prospective group, 8 of 11 patients had much reduced suppressor-cell activity before immunotherapy, and 7 of 11 patients had much reduced activity after immunotherapy. Non-specific T suppressor-cell activity is apparently reduced in allergic patients but immunotherapy does not restore such activity.