PYRIDOXINE DEFICIENCY in the HUMAN INFANT

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Abstract
Pyridoxine deprivation in two human infants resulted in an arrest of weight gain and failure of the ability to convert tryptophan to N1-methylnicotinamide in both. In one subject, it resulted in convulsive seizures; in the other it provoked a severe microcytic hypochromic anemia. All of these symptoms and signs were corrected by the introduction of pyridoxine into the diet. The ability to convert tryptophan to N1-methylnicotinamide is suggested as a biochemical test for pyridoxine deficiency in the human.