Effect of Hyperbaric Oxygen on Aerobic Bacteria in vitro and in vivo.

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Abstract
Strains of Escherichia coli, Aerobacter aerogenes, Pseudomonas aeruginosa, Salmonella typhimurium, Proteus mirabilis, Diplococcus pneumoniae, Staphylococcus aureus, and Streptococcus pyogenes in broth multiplied in O2 at 30 lbs./in.2 absolute (p.s.i.a.). The rate of growth and the peak titer achieved was frequently inhibited in O2 as compared with air at 15 p.s.i.a. The inhibitory effect of O2 was most marked with S. typhimurium, D. pneumoniae and S. aureus and was minimal or absent with P. mirabilis, A. aerogenes and E. coli. In general, 24 hr. cultures were more susceptible to the inhibitory activity of O2 than 4 hr. cultures. Each of the strains of aerobic bacteria grew on the surfaces of agar plates when incubated in O2 or air. Although equal numbers of colonies developed in O2 and air, differences in colonial morphology were noted in some of the strains incubated in O2. Exposure to O2 at 45 p.s.i.a. did not protect mice against death from infection produced by intravenous administration of D. pneumoniae, S. aureus or S. typhimurium.

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