Cold Urticaria and Photosensitivity Due to Griseofulvin

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Abstract
GRISEOFULVIN, the most effective systemic antibiotic in the treatment of superficial infections due to dermatophytes, has been used extensively in recent years. The side effects ascribed to the drug have been generally mild and insufficient to warrant withdrawal of therapy. Gastrointestinal symptoms such as nausea and vomiting, flatulence, heartburn, or diarrhea have been observed occasionally. Other reported reactions are dizziness, insomnia, fatigue, temporary proteinuria, peripheral neuritis, lethargy, mouth dryness, thirst, mental confusion, and impairment of performance of routine activities. Photosensitivity has been noted on rare occasions. Hypersensitivity manifested by urticaria, skin rashes, "serum sickness," vesicular eruptions, or severe angioedema may occur.1-7 The present report describes a case of cold urticaria and photosensitivity due to griseofulvin. Report of a Case A 44-year-old physician took griseofulvin for the second time because of a relapse of tinea pedis and tinea unguium due to Trichophyton mentagrophytes. In 1964 he had taken griseofulvin for

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