Phenotypic Markers in Chronic Lymphocytic Leukemia

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Abstract
To the Editor: Vitamin D–binding protein is present on the majority of normal human peripheral-blood B lymphocytes.1 Although the function of this protein is not known, it may be involved in linkage between surface immunoglobulin and actin2 and may also be a substrate for calcium–phospholipid-dependent creatine kinase.3 In view of this relation between B-cell activation on the one hand, and both cytoskeletal association of surface immunoglobulin2 and signal-induced creatine kinase activation4 on the other, these results suggest a possible role for vitamin D–binding protein in signal transduction, in addition to its function as the major carrier of vitamin D metabolites . . .

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