Novel mutations introduced at the β-site of amyloid β protein precursor enhance the production of amyloid β peptide by BACE1 in vitro and in cells
- 18 April 2005
- journal article
- Published by SAGE Publications in Journal of Alzheimer's Disease
- Vol. 7 (2) , 139-148
- https://doi.org/10.3233/jad-2005-7207
Abstract
Abnormal production and accumulation of amyloid-β peptide (Aβ) plays a major role in the pathogenesis of Alzheimer's disease (AD). β-secretase (BACE1) is responsible for the cleavage at the β-site in amyloid β protein precursor (AβPP/APP) to generateKeywords
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