Lewis Acid-Induced Intramolecular Friedel−Crafts Cyclization of 1,3-Bis-exocyclic Dienes. A New Route to 4a-Methyltetrahydrofluorenes
- 16 May 2003
- journal article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 5 (12) , 2055-2057
- https://doi.org/10.1021/ol0344265
Abstract
[reaction: see text] An efficient new method for constructing the 4a-methyltetrahydrofluorene skeleton was achieved via Friedel-Crafts intramolecular cyclization of 1,3-bis-exocyclic dienes. This strategy offers a simple and promising method for accessing complex structures.Keywords
This publication has 13 references indexed in Scilit:
- Cyclization of Aryllithiums Tethered to Methylenecycloalkanes: Stereoselective Synthesis of 4a-Substituted cis-HexahydrofluorenesThe Journal of Organic Chemistry, 2003
- Aromatase Inhibitory Activities of Standishinal and the Diterpenoids from the Bark of Thuja standishiiPlanta Medica, 2002
- Regiochemistry in Aryl Radical Cyclization onto MethylenecycloalkanesThe Journal of Organic Chemistry, 2000
- Standishinal, a novel carbon skeletal diterpene from the bark of Thuja standishii (Gord.) Carr.Published by Elsevier ,1999
- Rearranged abietane-type diterpenes from Salvia dichroanthaPhytochemistry, 1999
- An Efficient Palladium Catalyzed Stereocontrolled Synthesis of 4a-Angular Methyl Substituted HydrofluorenesSynthetic Communications, 1995
- An efficient stereoselective synthesis of .DELTA.4,5-pipecolic estersThe Journal of Organic Chemistry, 1992
- PrefaceTetrahedron Organic Chemistry Series, 1990
- Synthetic studies directed to gibberellins and related compoundsTetrahedron, 1968
- Acid-catalized cylisation of substituted benzylcyclohexanols. Factors influencing the nature of cyclisation products.Tetrahedron Letters, 1966