Capillary Flow and Capillary Transport in Dog Skeletal Muscle in an Experimental Shock Model (Laparatomy and Exteriorisation of the Small Intestine)

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Abstract
The transport of small water-soluble ions in dog skeletal muscle in relation to capillary blood flow has been studied by comparing the washout of iodide and xenon from intramuscular depots in control, in shock induced by exteriorisation of the intestines and after replacement of the intestines and infusion of LMWD. It was concluded that the transport of iodide was diffusion-limited in resting and vasodilated muscle in control and that there was a reversible reduction of diffusional transport in shock. LMWD reversed this disturbance. Such a disturbance would lead to an increasing concentration of metabolites in the muscle tissue out of proportion to the increase found in blood draining muscular veins, that is a hidden tissue acidosis. The explanation for this disturbance may be related to a disturbed distribution of flow through the capillary bed.

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