Über eine neue Methode zur positionsselektiven Einführung von Trifluormethyl-Gruppen in Heteroaromaten, Teil1. Synthese von trifluormethyl-substituierten 1,3-Azolen (Oxazole, Thiazole, Imidazole)

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Abstract
A New Method for Regioselective Introduction of Trifluoromethyl Groups into Heteroarenes; Part 1. Synthesis of Trifluoromethyl-substituted 1,3-Azoles (Oxazoles, Thiazoles, Imidazoles) The reaction of 4,4-bis(trifluoromethyl) -substituted hetero-1,3-dienes [N-(Hexafluoro-2-propylidene)carboxamides, -thiocarboxamides, and -amidines] with tin(II) chloride affords 5-fluoro-4-trifluoromethyl- oxazoles, -thiazoles, and -imidazoles, respectively. The reaction sequence involves heterocyclic tin(IV) compounds as intermediates.

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