Lithium Increases Platelet Count

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Abstract
To the Editor: Lithium carbonate, the primary treatment for manic-depressive illness, has consistently been reported to increase leukocyte counts1 , 2 without affecting erythrocytes or reticulocytes,1 when administered in therapeutic doses. Some3 , 4 but not all studies5 , 6 have reported increased platelet counts: these, however, are limited by the brief (one to two weeks4 , 5) or variable duration3 of lithium therapy, the use of comparison data from unmedicated controls rather than paired data,4 and the failure to compare directly the effect of lithium on platelets and white cells in the same patients.3 Therefore, we studied the effects of acute lithium treatment on white-cell and . . .

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