Immunohistochemical and ultrastructural studies on beta cell destruction in NOD mouse, an animal model for type I diabetes mellitus.

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Abstract
Non-obese diabetic (NOD) mice were recently established as a model for type I diabetes mellitus. Immunohistochemical study revealed that Thy-1+ cells (most of the cells are Lyt1+ but some are Lyt2+) infiltrate pancreatic islets and selectively destroy beta cells, resulting in overt diabetes. Immunoelectron microscopical study demonstrated the contact of both Lyt1+ and Lyt2+ cells with beta cells. A close adhesion of Lyt2+ cells to beta cells were regularly observed, and pseudopodia-like protrusions of the organella-rich Lyt2+ cells into the beta cells, resulting in the degeneration of those cells, were frequently seen. By contrast, Lyt1+ cells were merely in loose contact with beta cells. These results suggest that Lyt2+ cells are involved in the direct destruction of beta cells in NOD mice.

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