Use of Bi‐Allelic Insertion/Deletion Polymorphisms as a Positive Control for Fetal Genotyping in Maternal Blood
- 5 September 2006
- journal article
- research article
- Published by Wiley in Annals of the New York Academy of Sciences
- Vol. 1075 (1) , 123-129
- https://doi.org/10.1196/annals.1368.016
Abstract
Abstract: Amplification of fetal DNA in maternal plasma is a new way for non‐invasive fetal genotyping in pregnancies at risk for disorders where the presence of a paternal DNA sequence contributes to the risk status of the fetus. We describe the use of a panel of 10 bi‐allelic highly polymorphic markers to ascertain the presence and amplification of fetal DNA in case the fetus is negative for the targeted paternal “disease” sequence.Keywords
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