Polarity of the Blood-Brain Barrier: Neutral Amino Acid Transport into Isolated Brain Capillaries
- 13 October 1978
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 202 (4364) , 225-227
- https://doi.org/10.1126/science.211586
Abstract
Capillary endothelial cells isolated from rat brain exhibit Na+-dependent uptake of the neutral amino acid analog alpha-(methylamino)isobutyric acid. Since studies in vivo demonstrate that this transport system is not present on the blood side of brain capillaries we conclude that Na+-dependent neutral amino acid transport is located on the brain side. Therefore, the luminal plasma membrane and the antiluminal plasma membrane appear to be functionally distinct. This polarity should permit brain capillary endothelial cells to actively regulate the internal milieu of the brain.This publication has 27 references indexed in Scilit:
- Capillary transport of amino acids in the developing brainExperimental Neurology, 1976
- Sugar transport by renal plasma membrane vesiclesThe Journal of Membrane Biology, 1975
- SYNTHETIC AMINO ACIDS AND THE NATURE OF l‐DOPA TRANSPORT AT THE BLOOD‐BRAIN BARRIERJournal of Neurochemistry, 1975
- Isolation of metabolically active capillaries from rat brain1,2Journal of Neurochemistry, 1975
- γ-Glutamyl Transpeptidase in Brain Capillaries: Possible Site of a Blood-Brain Barrier for Amino AcidsScience, 1974
- DISTINCT PATTERNS OF ENTRY OF TWO NONMETABOLIZABLE AMINO ACIDS INTO BRAIN AND OTHER ORGANS OF INFANT GUINEA PIGS1,2Journal of Neurochemistry, 1972
- LEUCINE TRANSPORT FROM THE VENTRICLES AND THE CRANIAL SUBARACHNOID SPACE IN THE CAT1Journal of Neurochemistry, 1972
- AMINO ACID TRANSPORT BY CHOROID PLEXUS IN VITRO1Journal of Neurochemistry, 1969
- Some Special Kinetic Problems of TransportPublished by Wiley ,1969
- THE BRAIN BARRIER SYSTEM‐II UPTAKE AND TRANSPORT OF AMINO ACIDS BY THE BRAIN*Journal of Neurochemistry, 1961