Plasmid Modification of Radiation and Chemical-mutagen Sensitivity in Pseudomonas aeruginosa
- 1 January 1977
- journal article
- research article
- Published by Microbiology Society in Journal of General Microbiology
- Vol. 98 (1) , 167-176
- https://doi.org/10.1099/00221287-98-1-167
Abstract
The R factor pMG2 protects P. aeruginosa against the lethal effects of UV and .gamma. irradiation, and methyl methanesulfonate and N-methyl-N''-nitro-N-nitrosoguanidine treatment. Enhanced survival occurs in strains of uvr+ rec+ (wild-type) genotype and a variety of uvr rec+ type mutants. No protection occurs in a recA-type mutant. The plasmid also enhances UV-induced mutagenesis. These effects may be due to host-cell controlled plasmid-determined DNA repair function(s). Studies on P. aeruginosa strains deficient in DNA polymerase I (polA) suggest that a plasmid-determined repair resynthesis function may be responsible for increased UV-survival and enhanced UV-mutability in pMG2-containing bacteria.This publication has 2 references indexed in Scilit:
- Increase in frequency of ultraviolet-induced mutation brought about by the colicine factor, colI in Salmonella typhimuriumMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1966
- Resistance to the Bactericidal Effect of Ultraviolet Radiatic Conferred on Enterobacteria by the Colicine Factor collJournal of General Microbiology, 1965