Haemodialyser Reuse: Impact on Function and Biocompatibility

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Abstract
The functional performance (clearance of small molecules, ultrafiltration and blood loss) and biocompatibility (haemodialysis leucopenia) has been studied for disposable flat plate and hollow fibre haemodialysers utilizing Cuprophan membranes on their first use, and compared with that obtained when reusing by a manual and automated technique. The results obtained relating to functional performance remain unchanged with the exception of blood loss which shows an increase compared with first use. Biocompatibility is modified on reuse but only if the membrane has not been exposed to a rinsing process using sodium hypochlorite.