Comparison of virulence of clones of twoTrichomonas vaginalis strains by the subcutaneous mouse assay

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Abstract
No statistical differences in virulence were found among five clones isolated from each of twoTrichomonas vaginalis strains JH31A and Balt 42. The former strain, isolated from a patient showing no cervical epithelial abnormalities, caused relatively small subcutaneous lesions in mice [mean volume for the noncloned strain, 75.45±4.43 mm3 (n=70); mean of means for cloned populations, 77.28±3.14 mm3 (n=230)]. The latter, Balt 42, isolated from a woman with an in situ carcinoma of the cervix uteri, produced large subcutaneous abscesses in mice [mean volume for the noncloned strain, 202.28±12.53 mm3 (n=55); mean of means for cloned populations, 200.48±13.72 mm3 (n=264)]. The apparent homogeneity ofT. vaginalis strains with regard to virulence reinforces the dependability of the subcutaneous mouse assay.