Hayflick, his limit, and cellular ageing
Top Cited Papers
- 1 October 2000
- journal article
- other
- Published by Springer Nature in Nature Reviews Molecular Cell Biology
- Vol. 1 (1) , 72-76
- https://doi.org/10.1038/35036093
Abstract
Almost 40 years ago, Leonard Hayflick discovered that cultured normal human cells have limited capacity to divide, after which they become senescent — a phenomenon now known as the ‘Hayflick limit’. Hayflick's findings were strongly challenged at the time, and continue to be questioned in a few circles, but his achievements have enabled others to make considerable progress towards understanding and manipulating the molecular mechanisms of ageing.Keywords
This publication has 39 references indexed in Scilit:
- Telomerase and cellular lifespan: Ending the debate?Nature Biotechnology, 1998
- Telomeres, telomerase, and aging: Origin of the theoryExperimental Gerontology, 1996
- Specific Association of Human Telomerase Activity with Immortal Cells and CancerScience, 1994
- Telomeres shorten during ageing of human fibroblastsNature, 1990
- Identification of a specific telomere terminal transferase activity in tetrahymena extractsCell, 1985
- The myth of cell immortalityTrends in Biochemical Sciences, 1985
- A tandemly repeated sequence at the termini of the extrachromosomal ribosomal RNA genes in TetrahymenaJournal of Molecular Biology, 1978
- Nuclear control of cellular aging demonstrated by hybridization of anucleate and whole cultured normal human fibroblastsExperimental Cell Research, 1975
- A theory of marginotomyJournal of Theoretical Biology, 1973
- The biology of human agingThe Lancet Healthy Longevity, 1973