EFFECTS OF ADRIAMYCIN AND CYCLOPHOSPHAMIDE TREATMENT ON INDUCTION OF MACROPHAGE CYTOTOXIC FUNCTION IN MICE

  • 1 January 1979
    • journal article
    • research article
    • Vol. 39  (8) , 3014-3017
Abstract
The effects of i.p. and s.c. adriamycin and cyclophosphamide treatment of BALB/c .times. DBA/2 F1 mice were studied alone and in combination with immunotherapeutic agents, pyran copolymer and BCG, on macrophage cytotoxic ability. As assessed by direct viable cell counts of MBL-2 leukemia cells, adriamycin and cyclophosphamide produced growth-inhibitory macrophages. This function after s.c. cytostatic treatment peaked at day 1 and decreased progressively, attaining normal control values by day 6. When adjuvants, such as pyran and BCG, were administered i.p. simultaneously with s.c. adriamycin or cyclophosphamide, adjuvant-induced cytotoxic function was not markedly affected. A better knowledge of the influence was not markedly affected. A better knowledge of the influence of cytostatic agents alone or combined with immunoadjuvants on macrophage cytotoxic ability may be useful in designing more effective chemoimmunotherapy protocols.