Theophylline Disposition in Cystic Fibrosis1–4
- 1 April 1983
- journal article
- research article
- Published by American Thoracic Society in American Review of Respiratory Disease
- Vol. 127 (4) , 417-421
- https://doi.org/10.1164/arrd.1983.127.4.417
Abstract
The disposition of intravenously and orally administered theophylline was compared in 10 patients with cystic fibrosis (CF) and 10 healthy volunteers. The mean total body clearance of the patients with CF was twice that of the control subjects (p < 0.001). The volume of distribution of theophylline was also greater in the patients with CF (p < 0.05). These observations indicate that if theophylline is used in patients with CF, doses larger than those commonly given to asthmatics may be required to maintain therapeutic serum concentrations.This publication has 2 references indexed in Scilit:
- Aminoglycoside clearance inpatients with cystic fibrosisThe Journal of Pediatrics, 1979
- DISPOSITION OF THEOPHYLLINE AFTER A SINGLE INTRAVENOUS-INFUSION OF AMINOPHYLLINEPublished by Elsevier ,1978