Double-stranded-RNA-activated protein kinase (PKR) regulates Ca2+ stores in Xenopus oocytes
- 1 March 1998
- journal article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 330 (2) , 599-603
- https://doi.org/10.1042/bj3300599
Abstract
Expression of the double-stranded-RNA-dependent protein kinase (PKR) in Xenopus oocytes attenuated Ca2+ entry-dependent membrane currents activated by depletion of Ca2+ stores, whereas expression of a dominant-negative PKR mutant had the opposite effect. These results appeared to be due to perturbation of releasable Ca2+ stores, and not actions of PKR on protein synthesis. PKR may thus have novel protein substrates and cellular functions in Ca2+ storage and signalling.Keywords
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