Minimum infective dose of animal viruses

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Abstract
The potential for spread of viral and other infectious diseases is a function of the dose required to initiate an infection with either clinical or sub‐clinical sequelae. This is especially important for environmental spread where dilution and natural die‐off are generally assumed to play prominent roles in the control of disease. The use of disinfectants and other methods of pathogen destruction are common in certain instances but often a few survivors will eventually find routes back to their hosts. The importance of the minimum infectious dose is, therefore, evident. This report will review studies on the doses of different viruses required to initiate infection in animals and man.