The preparation of carbon-11 labelled diprenorphine: a new radioligand for the study of the opiate receptor system in vivo

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Abstract
Reaction of N-(de-cyclopropylmethyl)diprenorphine (3) with [1-11C]cyclopropanecarbonyl chloride (2), itself prepared from cyclotron-produced [11C]carbon dioxide, followed by reduction with LiAIH4, provides a fast and efficient route to carbon-11 labelled diprenorphine (7), a new radioligand for the study of the opiate receptor system in vivo.