Cell-Cell Interaction and Carcinogenesis
Open Access
- 1 April 1986
- journal article
- research article
- Published by SAGE Publications in Toxicologic Pathology
- Vol. 14 (3) , 363-369
- https://doi.org/10.1177/019262338601400313
Abstract
Before carcinogenic stimuli are introduced, a potentially cancerous cell functions normally; growth is controlled and the cell exists in complete harmony with that of surrounding cells in a given tissue. During the process of multi-stage carcinogenesis, such harmony is destroyed and a presumptive initiated cell accomplishes a clonal expansion, neglecting the growth pattern of surrounding normal cells. Recent results from our own laboratory and others strongly suggest that blocked gap-junctional intercellular communication is an important determinant during the process of tumor promotion.Keywords
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