Which diabetic patients should be taking aspirin?

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Abstract
Firstly, does it help? Several large studies have been conducted in diabetic patients, some aimed at preventing cardiovascular disease and others at slowing progression of retinopathy or nephropathy. The Veterans Administration study looked at the efficacy of aspirin and dipyridamole in preventing progression of cardiovascular and peripheral vascular disease in 231 diabetic men with limb gangrene or recent amputation for ischaemia.1 There were no differences in the incidence of either end point. The early treatment diabetic retinopathy study randomised 3711 patients with insulin dependent and non-insulin dependent diabetes to aspirin 650 mg daily or placebo.2 Patients treated with aspirin had 13% fewer cardiovascular deaths—a non-significant difference.