Neural Stem Cells and the Origin of Gliomas
Top Cited Papers
- 25 August 2005
- journal article
- review article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 353 (8) , 811-822
- https://doi.org/10.1056/nejmra043666
Abstract
Little progress has been made in the treatment of gliomas during the past 25 years. One reason is our poor understanding of the cell of origin in these tumors and of the mechanisms that bring that cell into a malignant state. This review argues that gliomas arise from neural stem cells and discusses the clinical implications of this concept.Keywords
This publication has 80 references indexed in Scilit:
- Unique astrocyte ribbon in adult human brain contains neural stem cells but lacks chain migrationNature, 2004
- Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferationNature, 2003
- Prospective identification of tumorigenic breast cancer cellsProceedings of the National Academy of Sciences, 2003
- Astrocytes Give Rise to Oligodendrogliomas and Astrocytomas after Gene Transfer of Polyoma Virus Middle T Antigen in VivoThe American Journal of Pathology, 2000
- Vascular niche for adult hippocampal neurogenesisJournal of Comparative Neurology, 2000
- The Hallmarks of CancerCell, 2000
- Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cellNature Medicine, 1997
- The neuroepithelial stem cell concept: Implications for neuro-oncologyJournal of Neuro-Oncology, 1995
- Primary Bioassay of Human Tumor Stem CellsScience, 1977
- The origin of experimental brain tumours: A sequential studyCellular and Molecular Life Sciences, 1976