Calmodulin Inhibition of Brain Membrane Phosphorylation

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Abstract
Calmodulin inhibited the phosphorylation of rat brain membrane proteins of MW 14,900-18,900 in a dose-dependent manner. This phenomenon was seen under conditions in which calmodulin simultaneously produced a stimulatory effect on the phosphorylation of proteins of MW 51,000 and above. This inhibition required Ca, but was not sensitive to cAMP or increasing ATP concentration and was not due to activation of a phosphatase. Calmodulin induces its inhibitory effects on phosphorylation by an indirect mechanism via a presently unknown pathway, or in addition to the kinase stimulated by calmodulin, there exists another distinct kinase which is inhibited by calmodulin.