A catalytic antibody elicited by a hapten of tetrahedral carbon-type
- 1 January 1994
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 11,p. 1355-1356
- https://doi.org/10.1039/c39940001355
Abstract
A monoclonal antibody, elicited by a α,α,α′,α′-tetrafluoroketone hapten, acted as an enzyme-like catalyst for the hydrolysis of an analogous carbonate, demonstrating that the difluoromethylene unit can been used as an isostere and isoelectronic mimic for the oxygen atom in an ether.Keywords
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