Bile Acid-Piperazine Diamides: Novel Steroidal Templates in Syntheses of Supramolecular Hosts: Isomeric Pyridine-n-carboxy Containing Dimers and a Cholaphane
- 31 December 2000
- journal article
- research article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 2000 (10) , 1464-1468
- https://doi.org/10.1055/s-2000-7113
Abstract
Novel steroidal dimers: 3α,3′α-dihydroxy-5β-cholan-24-oic acid piperazine diamide 3, its 3α,3′α-bis(trifluoroacetoxy) protected derivative 2, and 3α,3′α-bis(pyridine-n-carboxy, n = 2-4) derivatives 4-6 and their Ag+-complexes have been prepared. A novel cholaphane 7 has also been synthesized from 3 by cyclization with terephthalic acid by Yamaguchi method. Products were characterized by 13C and 15N NMR chemical shifts and MALDI-TOF MS. In addition, MO-calculations (PM3) for 3 and 7 were performed.Keywords
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