Switching Partners in a Regulatory Tango
- 21 December 2001
- journal article
- editorial
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 294 (5551) , 2497-2498
- https://doi.org/10.1126/science.1067622
Abstract
The coactivator CBP/p300 cooperates with the enzyme CARM1 to boost the activity of the nuclear hormone receptor transcription factors. But what is the relationship between CBP/p300 and CARM1? As Nishioka and Reinberg explain in their Perspective, new work reveals that CARM1 regulates the availability of CBP/p300 by methylating the KIX domain of this coactivator.Keywords
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