Methadone concentrations in plasma and their relationship to drug dosage
- 1 February 1991
- journal article
- research article
- Published by Oxford University Press (OUP) in Clinical Chemistry
- Vol. 37 (2) , 205-209
- https://doi.org/10.1093/clinchem/37.2.205
Abstract
We have developed a sensitive HPLC method for measuring methadone in plasma and have used it to establish that there is a linear relationship between plasma concentration and methadone dose over the range of 3-100 mg of methadone per day in a group of 31 addicts. We found a good correlation between dose and plasma concentration (r = 0.89), with the plasma methadone concentration increasing by 0.263 mg/L for every milligram of methadone consumed per kilogram of body weight. Five patients had unexpected high or low concentrations; this finding is discussed.Keywords
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