Convenient one-pot synthesis of cyclopropyl sulfones via successive alkylation and cyclization of sulfone-stabilized carbanions
- 1 January 1992
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 16,p. 2071-2074
- https://doi.org/10.1039/p19920002071
Abstract
A general one-pot approach to cyclopropyl sulfones has been demonstrated, which involves the alkyl-ation of lithiomethyl phenyl sulfone with an epoxide followed by cyclization of the resulting carbanion. Alkylation of the dianion derived from 3-arylsulfonylpropan-1-ol and subsequent one-pot cyclopropanation produced a regioisomer of the cyclopropyl sulfone.Keywords
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