Sarcoidosis and Major Histocompatibility Complex Genes with Special Emphasis on BF F Subtypes

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Abstract
Frequencies for HLA class I and II histoglobulins and C4A, C4B, BF complement proteins were performed for 59 sarcoidosis patients. The DR5 allele was present in 55.9% of patients as compared to 31.5% of controls. We noticed that its increase was more relevant in males and in those with a poor prognosis. BF F allele was significnatly overrepresented in patients (29.09 % vs. 19.15 % of control), especially in women. Special emphasis was given to BF F subtyping, to define an association between a particular BF F subtype and patient’s sex or disease outcome.

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