Induction of Mitosis in Macrophages by Endotoxin

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Abstract
Summary: A subcutaneous dose of 12 µg of lipopolysaccharide from Escherichia coli BV caused a peritoneal reaction which culminated in mitosis of free macrophages in the peritoneal fluid. The mitosis was preceded by a pronounced fall in the number of free macrophages. The appearances suggested, but did not prove, that macrophages were irreversibly damaged by the endotoxin or by products of its metabolism, and that new macrophages arose by transformation from lymphocytes and subsequent mitosis.