Analysis of Exposure‐Time‐Response Relationships Using a Spline Weight Function
- 1 December 2000
- journal article
- Published by Oxford University Press (OUP) in Biometrics
- Vol. 56 (4) , 1105-1108
- https://doi.org/10.1111/j.0006-341x.2000.01105.x
Abstract
Summary.To examine the time‐dependent effects of exposure histories on disease, we estimate a weight function within a generalized linear model. The shape of the weight function, which is modeled as a cubic B‐spline, gives information about the impact of exposure increments at different times on disease risk. The method is evaluated in a simulation study and is applied to data on smoking histories and lung cancer from a recent case‐control study in Germany.Keywords
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