Human Larynx Injected With Teflon Paste: Histologic Study of Innervation and Tissue Reaction

1 November 1967

journal article
case report
Published by American Medical Association (AMA) in JAMA Otolaryngology–Head & Neck Surgery

Vol. 86 (5) , 550-561
https://doi.org/10.1001/archotol.1967.00760050552014

Abstract

ONE OF US¹ recently reviewed the development of intrachordal injection procedures in the treatment of chronic vocal disability. After having experimented with various substances,^2,3 Arnold,⁴ in 1962, proposed the injection of Teflon granules suspended in glycerin. The present designation of the implant material is PTFE Paste for Injection (modified polytetrafluoro-ethylene, 50% weight in weight w/w in glycerin). This technique made it possible to revive the original idea published by Brünings⁵ in 1911 who injected paraffin for the correction of laryngeal paralysis. Numerous authors soon followed these suggestions and published their own experiences with the injection of granulated bone paste,^" silastic,⁷ Teflon,^8-11 glycerin,¹² and silicone.¹³ All these publications stressed the good functional results when suitable instances of this disability were treated with proper indication and correct techniques. Possible disappointments and their reasons have been discussed by Rubin.¹⁴ Further discussion of these

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