EFFECT OF IRON CONCENTRATION IN THE MEDIUM ON PHAGE AND TOXIN PRODUCTION IN A LYSOGENIC, VIRULENT CORYNEBACTERIUM DIPHTHERIAE

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Abstract
Relation betweeen phage and toxin production of a lysogenic, virulent C. diphtheriae C7([beta]) was determined in beef extract broth (5-7 [mu]g/ml), treated broth with precipitation by Ca3 (PO4)2 (O.I-0.5 [mu]g/ml), and iron readded treated broth (70 [mu]g/ml), by static and shaking culture for 24-48 hours at 37[degree]C respectively. Highest toxin production was observed by both culture in the treated broth, in which phage production was somewhat inferior to that in original broth. Furthermore, toxin titer in the iron readded treated broth decreased to that in original broth without any significant change of phage production. On the contrary, the iron concentration of the medium did not as seriously affect phage production as it did toxin production.

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