Mapping polypeptide hormone genes in the mouse: somatostatin, glucagon, calcitonin, and parathyroid hormone
- 1 January 1987
- journal article
- research article
- Published by S. Karger AG in Cytogenetic and Genome Research
- Vol. 44 (2-3) , 92-97
- https://doi.org/10.1159/000132350
Abstract
Mouse-Chinese hamster hybrids segregating mouse chromosomes were analyzed by Southern hybridization techniques to map the genes for somatostatin (Smst), glucagon (Gcg), calcitonin (Calc) and parathyroid hormone (Pth). The mouse gene for somatostatin, detected on a 20-kb EcoRl fragment, is located on mouse chromosome 16. Glucagon cDNA hybridized to a 14-kb EcoRl fragment residing on chromosome 2. Calcitonin and parathyroid hormone genes, detected on 7.8-kb HindIII and 6.0-kb BamHI fragments, respectively, were on mouse chromosome 7. The calcitonin and parathyroid hormone genes appear to be part of a larger linkage group which has been conserved in mouse and man.This publication has 4 references indexed in Scilit:
- Chromosome assignments of four mouse cellular homologs of sarcoma and leukemia virus oncogenes.Proceedings of the National Academy of Sciences, 1984
- Chromosome assignment of genes encoding the? and? subunits of glycoprotein hormones in man and mouseSomatic Cell and Molecular Genetics, 1983
- Chromosomal Assignment of the Endogenous Proto-Oncogene C- ablScience, 1982
- Biosynthesis of Parathyroid HormoneNew England Journal of Medicine, 1978