Liver glycerokinase deficiency in man with hyperglycerolaemia and hypertriglyceridaemia
- 1 April 1984
- journal article
- research article
- Published by Wiley in European Journal of Clinical Investigation
- Vol. 14 (2) , 103-106
- https://doi.org/10.1111/j.1365-2362.1984.tb02096.x
Abstract
Hyperglycerolemia and glyceroluria is described in a patient who presented transient dietary-induced hypertriglyceridemia. The increased glycerol in blood and urine was related to glycerokinase deficiency as evidenced by a hepatic tissue glycerokinase activity of 1/10 (4.8 .times. 10-5 mmol g-1 min-1) of that of normoglycerolemic subjects (5.9 .times. 10-4). As triglycerides are routinely determined by an enzymatic method after hydrolysis to glycerol, the differential diagnosis between true hypertriglyceridemia and hyperglycerolemia may prove difficult. Persisting hypertriglyceridemia despite adequate dietary and drug treatment should suggest the existence of undiagnosed hyperglycerolemia.Keywords
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