Human and Rat γ E: Serologic Evidence of Homology

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Abstract
The homocytotropic (reaginic) antibodies of several mammalian species resemble one another in their occurrence in trace amounts in serum following immunization, in their heat and sulfhydryl lability, and in their firm binding to target (mast) cells (1). Based on physicochemical characteristics, these homocytotropic antibodies have been identified as γE immunoglobulins in man, monkey, rabbit and rat (2–5). Antigenic relationships among the γE immunoglobulins of these species have been noted (3, 4, 6); the present report concerns the antigenic relationship between human γE (represented by myeloma protein PS (7)) and rat γE (represented by rat anti-Nippostrongylus brasiliensis homocytotropic antibodies (8)). Human myeloma proteins of the γG, γA, γD and γE class and a Waldenström γM protein were isolated by starch block electrophoresis, anion exchange chromatography and gel filtration according to conventional methods.

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