Anti‐LPS factor in the horseshoe crab, Tachypleus tridentatus

Abstract
Anti‐LPS factor, which inhibits the endotoxin mediated coagulation system in the horseshoe crab, Tachypleus tridentatus, was found to lyse red blood cells sensitized with gram‐negative bacterial LPS, but not to lyse unsensitized cells. This hemolysis occurred even at 0°C and was completed within 1 min. The binding of anti‐LPS factor to LPS must be essential for the hemolysis, because free LPS inhibited the hemolytic action of anti‐LPS factor.

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