Abstract
A review of the literature which is accumulating on the so-called tranquillizing drugs shows:1. A relatively small number of adequately controlled trials with, in general, more conservative conclusions than those of the much greater number of uncontrolled trials (Foulds, 1958).2. Diffuseness in patient selection, with subjects often being chosen for behavioural qualities (e.g. overactivity) or general characteristics (e.g. chronicity) rather than for diagnosis.